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In 2014, Takayama et al. [38] to start with tried to elucidate the in vitro metabolism of ADB-FUBINACA by analysing the metabolites produced by the exercise with the cytochrome P450 enzymes just after 1 h of incubation with human liver microsomes. Utilizing UPLC/ESI-MS/MS, the authors identified a single metabolite, ensuing from oxidation in the NS